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Serum homocysteine, methylenetetrahydrofolate reductase gene polymorphism and cardiovascular disease in heterozygous familial hypercholesterolemia

✍ Scribed by Livia Pisciotta; Claudio Cortese; Agostino Gnasso; Laura Liberatoscioli; Anna Pastore; Liliana Mannucci; Concetta Irace; Giorgio Federici; Stefano Bertolini

Book ID: 118420552
Publisher: Elsevier Science
Year: 2005
Tongue: English
Weight: 122 KB
Volume: 179
Category: Article
ISSN: 0021-9150
DOI: 10.1016/j.atherosclerosis.2004.10.016

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## Abstract Hyperhomocysteinemia is a risk factor for thrombosis, and methylenetetrahydrofolate reductase (__MTHFR__) and methionine synthase reductase (__MTRR__) polymorphisms, folate, and B~12~ levels could contribute to plasma homocysteine (Hcy) variation. Although well established in adults, fe