Serum free 5-methoxypsoralen fraction in health and psoriasis: relationship with human serum albumin concentration
✍ Scribed by P. Muret; P. Humbert; S. Makki; P. Bechtel; S. Urien; J. P. Tillement
- Book ID
- 104745506
- Publisher
- Springer-Verlag
- Year
- 1993
- Tongue
- English
- Weight
- 371 KB
- Volume
- 285
- Category
- Article
- ISSN
- 0340-3696
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✦ Synopsis
Human serum albumin is known to be the main carrier of 5-methoxypsoralen (5-MOP) in serum. As hypoalbuminaemia may occur in psoriasis with inflammatory syndrome, variability of the free 5-MOP fraction in serum can be expected. The free 5-MOP fraction was determined by equilibrium dialysis in serum samples obtained from 18 psoriatic patients and 18 control subjects. The median free 5-MOP fraction was not significantly different in the psoriatic group (fn = 4.75%) than in the control group (fu = 5%). However, there was a significantly larger variability of the free fraction in the psoriatic group (2.7 to 8.6%) than in the healthy group (3.2 to 6.8%) (p --0.002). The binding index of 5-MOP (ratio of bound to free concentrations) was correlated with human serum albumin level (r = 0.784). This work confirms that the 5-MOP fraction in human serum is principally serum albumin dependent, as has been described with in ,itro models. Free drug monitoring of 5-MOP is discussed.