Serum enzymes in disease. XIII. Comparison of glycolytic and oxidative enzyme and transaminase values in benign and malignant effusions with those in serums

✍ Scribed by Mark J. Brauer; Michael West; Hyman J. Zimmerman

• Publisher: John Wiley and Sons
• Year: 1963
• Tongue: English
• Weight: 657 KB
• Volume: 16
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(196304)16:4<533::aid-cncr2820160416>3.0.co;2-z

✦ Synopsis

A fluids has been employed in the effort to facilitate the diagnosis of malignant effusions. Neoplastic cells in tissue culture or suspension have been shown to release lactic dehydrogenase (LD) to the surrounding medium.l.5 Wr6blewski,lo-12 in 1957 and 1958, reported that malignant pleural and peritoneal effusions had greater LLI activity than the serum from the same patients. He did not observe this phenomenon with benign serous effusions and found it to be infrequently associated with "malignant" effusions with negative fluid Subsequent studies by several gr0ups2-~, 7 on the diagnostic significance of enzyme levels in the effusions of patients with malignant disease have led to conflicting results. de Tor-regrosa7 has reported that his data corroborate the observations of Wrbblewski on the high degree of sensitivity and specificity for neoplastic effusions of an elevated effusion-serum ratio of LD activity. Other studies with L D ~-4 and other enzymes2 have indicated lesser degrees of sensitivity for neoplastic disease as well as high ratios in a variety of benign effusions.

Accordingly, the present study was undertaken to evaluate this problem. The ratio of cytology.