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Serum-derived factors weaken the barrier properties of cultured porcine brain capillary endothelial cells in vitro

✍ Scribed by Thorsten Nitz; Tanja Eisenblätter; Katherina Psathaki; Hans-Joachim Galla


Book ID
113999538
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
576 KB
Volume
981
Category
Article
ISSN
0006-8993

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## Abstract Claudins are thought to be major components of tight junctions (TJs), and claudin‐5 and ‐12 are localized at TJs of the blood‐brain barrier (BBB). Claudin‐5‐deficient mice exhibit size‐selective (<800 Da) opening of the BBB. The purpose of this study was to clarify the expression levels