Serum-dependent changes of intracellular Na+ and K+ concentrations in cultured human fibroblasts
β Scribed by DALLASTA, V; REBECCHI, F; LONGO, N; BUSSOLATI, O; GAZZOLA, G
- Book ID
- 123172308
- Publisher
- Elsevier Science
- Year
- 1986
- Tongue
- English
- Weight
- 65 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0309-1651
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Stimulation of an amiloride-sensitive Na+ influx pathway, which mediates Na+/H+ exchange, has been postulated to be an important step in the initiation of DNA synthesis in quiescent human fibroblasts. If the elevation of intracellular Na+ or the alkalinization of intracellular pH resulting from the
## New lersey 07 I03 Previously, we demonstrated that removal of fetal bovine serum (FBS) from the medium of human skin fibroblasts resulted in an accelerated '%b' washout, decreased cellular K i , and increased Na' contents. In the present study we examined the mechanism underlying these changes.