𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Serum concentrations of laminin γ2 fragments in patients with head and neck squamous cell carcinoma

✍ Scribed by Yuichiro Kuratomi; Shintaro Sato; Mikio Monji; Rintaro Shimazu; Gou Tanaka; Kyoko Yokogawa; Akiko Inoue; Akira Inokuchi; Masahiko Katayama

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
159 KB
Volume
30
Category
Article
ISSN
1043-3074

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background

The laminin (LN) γ2 chain expression has been linked to tumor invasion and prognosis. To provide a convenient clinical use, procedures that analyze LNγ2 expression by using the serum and/or urine of patients should be developed.

Methods

The serum concentrations of the N‐terminal fragments of the LNγ2 chain in 73 patients with head and neck squamous cell carcinomas were measured by immunoassay.

Results

The concentrations of the LNγ2 fragments ranged between 14.5 and 324.2 ng/mL, and the normal upper limit was estimated to be 50 ng/mL. The LNγ2 fragment concentrations increased according to the T classification. The amount of elevated LNγ2 fragment concentrations decreased after the use of curative treatments. Three patients displayed a continuous increase of the concentrations and subsequently died of the diseases.

Conclusions

The serum concentrations of the LNγ2 fragments may prove useful in assessing the treatment results and clinical courses of patients with head and neck squamous cell carcinomas. © 2008 Wiley Periodicals, Inc. Head Neck, 2008

📜 SIMILAR VOLUMES

Efficacy of neck treatment in patients w
Efficacy of neck treatment in patients with head and neck squamous cell carcinoma
✍ Gabriela Buck; Pia Huguenin; Sandro J. Stoeckli 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 131 KB 👁 2 views

## Abstract ## Background. Treatment of head and neck squamous cell carcinoma (HNSCC) addresses the primary tumor and the lymphatic drainage. Modalities for the neck are neck dissection and/or radiation therapy. In most cases, the neck is treated by the modality that seems more appropriate for the

Radioimmunotherapy in patients with head
Radioimmunotherapy in patients with head and neck squamous cell carcinoma: Initial experience
✍ David R. Colnot; Jasper J. Quak; Jan C. Roos; Remco de Bree; Abraham J. Wilhelm; 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 186 KB 👁 2 views

## Abstract ## Background Despite improvements in locoregional treatment of stages III/IV squamous cell carcinoma of the head and neck (HNSCC), local and distant failure rates remain high. An effective adjuvant therapy is required for these patients. Among novel approaches is radioimmunotherapy, i

Immunoglobulin allotypes in patients wit
Immunoglobulin allotypes in patients with squamous cell carcinoma of the head and neck
✍ Theodorus Ockhuizen; Janardan P. Pandey; Robert W. Veltri; Myron Arlen; H. Hugh 📂 Article 📅 1982 🏛 John Wiley and Sons 🌐 English ⚖ 403 KB 👁 2 views

Gm, A2m, and Km allotypic markers were examined in 40 Caucasian patients with squamous cell carcinomas of the head and neck. Serum IgA levels, the A2m(l) allotypic marker, and antibodies against IgAl, A2m(l), and A2m(2) were measured quantitatively. The frequency of Km(1) was found to be significant

Aberrant cytokine expression in serum of
Aberrant cytokine expression in serum of patients with adenoid cystic carcinoma and squamous cell carcinoma of the head and neck
✍ Thomas K. Hoffmann; Eniko Sonkoly; Bernhard Homey; Katrin Scheckenbach; Christia 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 157 KB 👁 2 views

## Abstract ## Background. Squamous cell carcinoma (SCC) and adenoid cystic carcinoma (ACC) represent 2 clinically important subtypes of head and neck cancer. Our objective was to characterize and compare cytokine profiles in the systemic circulation of patients with SCC and ACC. ## Methods. Mul