Autocrine activation of the IL-3/GM-CSF/
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Paul, Cassandra C.; Mahrer, Susan; McMannama, Karyle; Baumann, Michael A.
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Article
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1997
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John Wiley and Sons
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English
โ 454 KB
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The AML14.3D10 human myeloid leukemic cell line expresses receptors for granulocytemacrophage colony stimulating factor (GM-CSF) and interleukin-5 (IL-5), but not IL-3. We have found that this cell line produces GM-CSF in amounts up to 113 pg/ml in culture supernatants. Deprivation of endogenous GM-