Serum concentrations of four immunoglobulins in non-immunized and immunized athymic (‘nude’) mice
✍ Scribed by Dieter H. Sussdorf; Richard L. McCann
- Book ID
- 115942677
- Publisher
- Elsevier Science
- Year
- 1975
- Weight
- 253 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0019-2791
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This study assessed the residual immunity possessed by NCr/Sed (nu/nu) athymic nude mice and examined strategies to reduce it in order to enhance the transplantability of human tumors for experimentation. Adult (8-week-old) female mice had fewer T cells (I I%) and more B and N K (asialo-GM,-positive
## Abstract Human malignant lymphoma cells may be readily heterotransplanted into the brains of athymic nude mice. We have examined humoral immune responses to these lymphoma cells and have found a primary cytotoxic IgM and a late cytotoxic IgG response. Nude mice with tumors growing intracerebrall