Serum concentrations of DKK-1 decrease in patients with multiple myeloma responding to anti-myeloma treatment
β Scribed by Ulrike Heider; Martin Kaiser; Maren Mieth; Britta Lamottke; Jessica Rademacher; Christian Jakob; Edgar Braendle; David Stover; Orhan Sezer
- Book ID
- 114794493
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 224 KB
- Volume
- 82
- Category
- Article
- ISSN
- 0902-4441
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## Abstract Hepatocyte growth factor (HGF) has been shown to be involved in angiogenesis, epithelial cell proliferation, and osteoclast activation. HGF and its receptor are expressed on myeloma cell lines and could be involved in the pathogenesis of bone destruction in multiple myeloma (MM). The ai
## Abstract Dickkopfβ1 (DKKβ1) protein, a soluble inhibitor of Wnt signalling, has been implicated in the pathogenesis of myeloma bone disease through the suppression of osteoblast differentiation. In this study, serum concentrations of DKKβ1 were measured in 50 myeloma patients (32 at diagnosis an