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Serum concentrations of clozapine and norclozapine in the prediction of relapse of patients with schizophrenia

✍ Scribed by Ying-Qiang Xiang; Zhang-Jin Zhang; Yong-Zhen Weng; Yi-Min Zhai; Wen-Biao Li; Zhuo-Ji Cai; Qing-Rong Tan; Chuan-Yue Wang

Book ID
119362660
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
241 KB
Volume
83
Category
Article
ISSN
0920-9964

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Measurement of clozapine and norclozapin
Measurement of clozapine and norclozapine in plasma/serum by high performance liquid chromatography with ultraviolet detection
✍ P. T. McCarthy; S. Hughes; C. Paton πŸ“‚ Article πŸ“… 1995 πŸ› John Wiley and Sons 🌐 English βš– 579 KB

A simple method for the measurement of clozapine and its A'-desmethyl metabolite in human plasma or serum by high performance liquid chromatography is described. An internal standard (aqueous nortriptyline, 4 mg/L) (50 pL) and Tris buffer (2 mol/L, pH 10.6) (100 pL) are added to plasma/serum (200 pL