Serum Concentration of Chorionic Gonadotropin-like Substance and Luteinizing Hormone in Children Measured by Sensitive Enzyme Immunoassay
✍ Scribed by Koichi Yano; Akimasa Okuno; Seiichi Hashida; Eiji Ishikawa
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 362 KB
- Volume
- 2
- Category
- Article
- ISSN
- 0887-8013
No coin nor oath required. For personal study only.
✦ Synopsis
Serum levels of human chorionic gonadotropin (hCG)-like substance and human luteinizing hormone (hLH) in healthy children aged 4-17 years were measured by sensitive enzyme immunoassay techniques. In enzyme immunoassay for hCGlike substance, minimal cross-reaction with hLH was observed. In enzyme immunoassay for hLH, there was a considerable cross-reaction with hCG. However, serum levels of hCG-like substance were below 0.08 IUlliter or less than one fourth of serum hLH levels. Therefore, values ob-tained for serum hLH levels were considered to be reliable. Serum levels of hCGlike substance increased with increasing ages in some children, with the highest level 0.23 IUlliter in a male aged 14 years. Serum hLH levels were 0.02-0.7 IUlliter in children aged 4-8 years, elevated during the ages of 9 to 11 years, reaching the range of 3-27 IUlliter in children aged 12-17 years. The sensitive enzyme immunoassay technique used in this study will be useful for the detection of hypogonadotropic hypogonadism in children.