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Serum can inhibit reversal of multidrug resistance by chemosensitisers

โœ Scribed by M. Lehnert; R. de Giuli; K. Kunke; S. Emerson; W.S. Dalton; S.E. Salmon


Book ID
116167840
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
794 KB
Volume
32
Category
Article
ISSN
0959-8049

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The multidrug-resistance (MR) status of camptothecin (CPT) was investigated in colon adenocarcinoma HT29 cells, leukemia K562, and breast carcinoma MCF7 cells expressing P-glycoprotein (Pgp) and/or MR-associated protein (MRP1). The concentration that induced 50% growth inhibition (IC(50)) against CP