Serum bile acids and their conjugates in breast-fed infants with prolonged jaundice

✍ Scribed by Y. Tazawa; M. Yamada; M. Nakagawa; T. Konno; K. Tada

• Book ID: 104786296
• Publisher: Springer
• Year: 1985
• Tongue: English
• Weight: 326 KB
• Volume: 144
• Category: Article
• ISSN: 0340-6997
• DOI: 10.1007/bf00491922

✦ Synopsis

Serum bile acids and their conjugates were analysed in 20 breast-fed infants with prolonged jaundice. The mean total bile acid levels in serum were increased in the breast-fed infants with jaundice, as compared with those in either breastor bottle-fed infants without jaundice. However, there were no significant differences between the groups. All the breastfed infants examined, regardless of association with jaundice, had a bile acid pattern dominated by taurine conjugates (the ratio of glycine-to taurine-conjugated bile acid, G/T ratio, less than 1.00). In contrast, the bottle-fed infants without jaundice had a pattern dominated by glycine conjugates (G/T ratio, more than 1.00). Among the breast-fed infants with jaundice, the mean G/T ratio in those who had serum bilirubin levels over 10 rag/100 ml was significantly lower than that in those who had serum bilirubin levels of less than 10 mg/100 ml. The altered bile acid metabolism might be associated with the pathology of breast milk jaundice.