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Serum beta 2 microglobulin in adult myeloid acute leukemias

✍ Scribed by Campos, L. ;Vu Van, H. ;Ville, D. ;Imbert, C. ;Gentilhomme, O. ;Luo, Y. C. ;Fiere, D. ;Viala, J. J.

Publisher
Springer-Verlag
Year
1984
Weight
351 KB
Volume
48
Category
Article
ISSN
1432-0584

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✦ Synopsis

Serum beta 2 microglobulin levels, measured by radioimmunoassay (Phadebas test), were found increased in acute myeloid leukemias at diagnosis. Serum beta 2 microglobulin levels were significantly higher in patients with monocytic leukemias (13 patients, M4-M5 FAB classification) than in those with other cytological types (18 patients). Beta 2 microglobulin levels at diagnosis were correlated with serum lysozyme levels, but they were not correlated with blood blast counts, serum LDH and ferritin levels. 195 serum beta 2 microglobulin measurements were made serially in 30 patients with acute myeloid leukemias in first remission. Compared to values at diagnosis, beta 2 microglobulin levels in remission were significantly decreased. Out of 30 patients in remission 12 had increased serum beta 2 microglobulin levels (greater than 3 mg/l). Serial measurements were not predictive for relapses.

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