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Serum antibodies against the hepatitis C virus E2 protein mediate antibody-dependent cellular cytotoxicity (ADCC)

✍ Scribed by Jacob Nattermann; Angelika Maria Schneiders; Ludger Leifeld; Bettina Langhans; Monika Schulz; Geneviève Inchauspé; Bertfried Matz; Hans H. Brackmann; Michael Houghton; Tilman Sauerbruch; Ulrich Spengler


Book ID
116650611
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
207 KB
Volume
42
Category
Article
ISSN
0168-8278

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A recombinant subunit antigen (ORF2.1), representing the carboxy-terminal 267 amino acids of the 660-amino-acid hepatitis E virus (HEV) capsid protein, was expressed in Escherichia coli and used for the immunisation of rats. Purified antigen formulated with either Aluminium Hydroxide Gel Adjuvant (A