𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Serum androgens and prostate cancer among 643 cases and 643 controls in the European Prospective Investigation into Cancer and Nutrition

✍ Scribed by Ruth C. Travis; Timothy J. Key; Naomi E. Allen; Paul N. Appleby; Andrew W. Roddam; Sabina Rinaldi; Lars Egevad; Peter H. Gann; Sabine Rohrmann; Jakob Linseisen; Tobias Pischon; Heiner Boeing; Nina Føns Johnsen; Anne Tjønneland; Kim Overvad; Lambertus Kiemeney; H. Bas Bueno-de-Mesquita; Sheila Bingham; Kay-Tee Khaw; Rosario Tumino; Sabina Sieri; Paolo Vineis; Domenico Palli; José Ramón Quirós; Eva Ardanaz; Maria-Dolores Chirlaque; Nerea Larrañaga; Carlos Gonzalez; Maria-José Sanchez; Antonia Trichopoulou; Chrysa Bikou; Dimitrios Trichopoulos; Pär Stattin; Mazda Jenab; Pietro Ferrari; Nadia Slimani; Elio Riboli; Rudolf Kaaks

Publisher
John Wiley and Sons
Year
2007
Tongue
French
Weight
115 KB
Volume
121
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

We examined the hypothesis that serum concentrations of circulating androgens and sex hormone binding globulin (SHBG) are associated with risk for prostate cancer in a case‐control study nested in the European Prospective Investigation into Cancer and Nutrition (EPIC). Concentrations of androstenedione, testosterone, androstanediol glucuronide and SHBG were measured in serum samples for 643 prostate cancer cases and 643 matched control participants, and concentrations of free testosterone were calculated. Conditional logistic regression models were used to calculate odds ratios for risk of prostate cancer in relation to the serum concentration of each hormone. After adjustment for potential confounders, there was no significant association with overall risk for prostate cancer for serum total or free testosterone concentrations (highest versus the lowest thirds: OR, 1.02; 95% CI, 0.73–1.41 and OR, 1.07, 95% CI, 0.74–1.55, respectively) or for other androgens or SHBG. Subgroup analyses showed significant heterogeneity for androstenedione by cancer stage, with a significant inverse association of androstenedione concentration and risk for advanced prostate cancer. There were also weak positive associations between free testosterone concentration and risk for total prostate cancer among younger men and risk for high‐grade disease. In summary, in this large nested case‐control study, concentrations of circulating androgens or SHBG were not strongly associated with risk for total prostate cancer. However, our findings are compatible with a positive association of free testosterone with risk in younger men and possible heterogeneity in the association with androstenedione concentration by stage of disease; these findings warrant further investigation. © 2007 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Tobacco smoke and bladder cancer—in the
Tobacco smoke and bladder cancer—in the European prospective investigation into cancer and nutrition
✍ Bine Kjøller Bjerregaard; Ole Raaschou-Nielsen; Mette Sørensen; Kirsten Frederik 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 77 KB 👁 2 views

## Abstract The purpose of the present study was to investigate the association between smoking and the development of bladder cancer. The study population consisted of 429,906 persons participating in the European Prospective Investigation into Cancer and Nutrition (EPIC), 633 of whom developed bl

Physical activity and risk of prostate c
Physical activity and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
✍ Nina Føns Johnsen; Anne Tjønneland; Birthe L.R. Thomsen; Jane Christensen; Steff 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 126 KB 👁 2 views

## Abstract The evidence concerning the possible association between physical activity and the risk of prostate cancer is inconsistent and additional data are needed. We examined the association between risk of prostate cancer and physical activity at work and in leisure time in the European Prospe

Fruits and vegetables and prostate cance
Fruits and vegetables and prostate cancer: No association among 1,104 cases in a prospective study of 130,544 men in the European Prospective Investigation into Cancer and Nutrition (EPIC)
✍ Timothy J. Key; Naomi Allen; Paul Appleby; Kim Overvad; Anne Tjønneland; Anthony 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 100 KB 👁 1 views

We examined the association between self-reported consumption of fruits and vegetables and prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Data on food consumption and complete follow-up for cancer incidence were available for 130544 men in 7 countrie

Anthropometric measures and epithelial o
Anthropometric measures and epithelial ovarian cancer risk in the European Prospective Investigation into Cancer and Nutrition
✍ Petra H. Lahmann; Anne E. Cust; Christine M. Friedenreich; Mandy Schulz; Annekat 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 French ⚖ 184 KB 👁 2 views

## Abstract We examined the associations of measured anthropometric factors, including general and central adiposity and height, with ovarian cancer risk. We also investigated these associations by menopausal status and for specific histological subtypes. Among 226,798 women in the European Prospec

Physical activity and lung cancer risk i
Physical activity and lung cancer risk in the European Prospective Investigation into Cancer and Nutrition Cohort
✍ Karen Steindorf; Christine Friedenreich; Jakob Linseisen; Sabine Rohrmann; Andre 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 French ⚖ 120 KB 👁 2 views

## Abstract Research conducted predominantly in male populations on physical activity and lung cancer has yielded inconsistent results. We examined this relationship among 416,277 men and women from the European Prospective Investigation into Cancer and Nutrition (EPIC). Detailed information on rec

Cigar and pipe smoking and cancer risk i
Cigar and pipe smoking and cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)
✍ Valerie A. McCormack; Antonio Agudo; Christina C. Dahm; Kim Overvad; Anja Olsen; 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 226 KB 👁 2 views

## Abstract The carcinogenicity of cigar and pipe smoking is established but the effect of detailed smoking characteristics is less well defined. We examined the effects on cancer incidence of exclusive cigar and pipe smoking, and in combination with cigarettes, among 102,395 men from Denmark, Germ