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Serum and urinary biotin levels during treatment of holocarboxylase synthetase deficiency

โœ Scribed by K.S. Roth; L. Allan; W. Yang; J.W. Foreman; K. Dakshinamurti


Book ID
115823593
Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
271 KB
Volume
109
Category
Article
ISSN
0009-8981

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Holocarboxylase synthetase is one of two enzymes known to be involved in the metabolism of biotin. It catalyses the fixation of biotin to inactive apocarboxylases yielding active carboxylases. Deficiency of this enzyme leads to multiple carboxylase deficiency which is fatal in the absence of prompt