Serum alpha1-fetoprotein in cystic fibrosis

✍ Scribed by G. Knöpfle; H. W. Rotthauwe; F. -G. Lehmann

• Book ID: 104783367
• Publisher: Springer
• Year: 1976
• Tongue: English
• Weight: 534 KB
• Volume: 122
• Category: Article
• ISSN: 0340-6997
• DOI: 10.1007/bf00481503

✦ Synopsis

In 38 children and adolescents with cystic fibrosis, in 19 normal children and 62 healthy adults the serum al-fetoprotein concentrations were measured by radioimmunoassay. In cystic fibrosis patients 97.5~o and in normal children 95~o of the al-fetoprotein values were within the normal range for healthy adults (1--9 ng/ml). Critical judgement of the reported findings in literature and our own results demonstrate that the investigation of al-fetoprotein in the serum cannot serve for detecting homozygotes of cystic fibrosis genes or heterozygote carriers.