Serum alpha-fetoprotein as a marker for the effect of post-operative radiation therapy and/or chemotherapy in eight cases of ovarian endodermal sinus tumour

✍ Scribed by A. Sell; H. Søgaard; B. Nørgaard-Pedersen

• Publisher: John Wiley and Sons
• Year: 1976
• Tongue: French
• Weight: 522 KB
• Volume: 18
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910180505

✦ Synopsis

Abstract

The clinical pathological findings of eight cases of ovarian endodermal sinus tumour (yolk sac tumour) are presented. Histological examination in all eight cases showed a typical endodermal sinus tumour pattern, and in six of the patients other tumour elements such as dysgerminoma, choriocarcinoma, malignant teratoma, endometriosis, and a dermoid cyst were also found. Six patients had increased serum alpha‐fetoprotein concentration in the postoperative period, and two patients had a normal concentration 27 and 35 days after operation, respectively. In all cases except one, a close correlation between serum alpha‐fetoprotein and progression or regression of tumour was found. Serum alpha‐fetoprotein was thus found to be a reliable parameter in post‐operative radiation and/or chemotherapy (VAMBLE). In one patient who died 10 months after operation with widespread endodermal sinus tumour growth, only a small terminal increase in serum alpha‐fetoprotein concentration was found. Four of the eight women are still alive with normal alpha‐fetoprotein concentration, and without clinical evidence of tumour disease.