Induced expression of plasminogen activator inhibitor type-1 (PAI-1), a major negative regulator of pericellular plasmin generation, accompanies wound repair in vitro and in vivo. Since transcriptional control of the PAI-1 gene is superimposed on a growth state-dependent program of cell activation (
✦ LIBER ✦
SERPINE1 (PAI-1) is deposited into keratinocyte migration “trails” and required for optimal monolayer wound repair
✍ Scribed by Kirwin M. Providence; Stephen P. Higgins; Andrew Mullen; Ashley Battista; Rohan Samarakoon; Craig E. Higgins; Cynthia E. Wilkins-Port; Paul J. Higgins
- Book ID
- 106078824
- Publisher
- Springer-Verlag
- Year
- 2008
- Tongue
- English
- Weight
- 446 KB
- Volume
- 300
- Category
- Article
- ISSN
- 0340-3696
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Several proteases and their specific inhibitors modulate the interdependent processes of cell migration and matrix proteolysis as part of the global program of trauma repair. Expression of plasminogen activator inhibitor type-1 (PAI-1), a serine protease inhibitor (SERPIN) important in the control o