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Serpin-resistant mutants of human tissue-type plasminogen activator

โœ Scribed by Madison, Edwin L.; Goldsmith, Elizabeth J.; Gerard, Robert D.; Gething, Mary-Jane H.; Sambrook, Joseph F.


Book ID
109759318
Publisher
Nature Publishing Group
Year
1989
Tongue
English
Weight
535 KB
Volume
339
Category
Article
ISSN
0028-0836

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Full-length tissue-type plasminogen activator (t-PA) cDNA served to construct deletion mutants within the N-terminal "heavy" (H)-chain of the t-PA molecule. The H-chain cDNA consists of an array of structural domains homologous to domains present on other plasma proteins ("finger, " "epidermal growt