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Serotonin1A-receptor agonism attenuates the cocaine-induced increase in serotonin levels in the hippocampus and nucleus accumbens but potentiates hyperlocomotion: an in vivo microdialysis study

✍ Scribed by C.P Müller; R.J Carey; J.B Salloum; J.P Huston


Book ID
117187588
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
276 KB
Volume
44
Category
Article
ISSN
0028-3908

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Hippocampus 5-HT1A-receptors attenuate c
✍ Christian P. Müller; Heike Thönnessen; Marilia Barros; Carlos Tomaz; Robert J. C 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 758 KB

Cocaine induces an increase in hippocampal and nucleus accumbens (Nac) serotonin (5-HT) concentration parallel to locomotor activation. Both effects can be modulated by systemic 5-HT 1A -receptor agonism/antagonism. Given the contribution of the hippocampus to spontaneous behavioral activity, these