Serotonin-sensitive leakage channel inDrosophila central neurons

✍ Scribed by Wright, Nicholas J. D. ;Zhong, Yi

• Publisher: John Wiley and Sons
• Year: 1998
• Tongue: English
• Weight: 246 KB
• Volume: 34
• Category: Article
• ISSN: 0022-3034
• DOI: 10.1002/(sici)1097-4695(199801)34:1<83::aid-neu7>3.0.co;2-8

✦ Synopsis

This article reports the analysis of hyperpolarizing response is in fact mediated by inhiba novel serotonin (5-HT)-sensitive leak channel. The iting an inward leak current, which has a reversal 5-HT responses were recorded in acutely dissociated potential around 0 mV. This 5-HT-sensitive leak cur-Drosophila adult and larval central nervous system rent appears to be mediated mainly by one type of (CNS) neurons by the patch-clamp method, in an atnewly identified leak channel with a similar reversal tempt to establish a model preparation suitable for potential of 0 mV and a conductance of 24 pS. In the genetic study of signal transduction underlying addition, it was also demonstrated that neurotranscentral neurotransmission. Focal perfusion or iontomitter-induced responses in both larval and adult phoresis of 5-HT onto some patched neurons induced Drosophila CNS neurons can be analyzed in this either an apparent inward or outward current. This acutely dissociated preparation. ᭧ 1998 John Wiley & apparent outward current is able to cause a strong