Serotonin 5-HT2A receptors are expressed on pyramidal cells and interneurons in the rat cortex

✍ Scribed by David L. Willins; Ariel Y. Deutch; Bryan L. Roth

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 236 KB
• Volume: 27
• Category: Article
• ISSN: 0887-4476
• DOI: 10.1002/(sici)1098-2396(199709)27:1<79::aid-syn8>3.0.co;2-a

✦ Synopsis

The distribution of 5-HT 2A receptors in rat cortex was evaluated using newly developed antibodies. Each of three antibodies tested identified an identical pattern of 5-HT 2A -like immunoreactivity (5-HT 2A -li) in rat cortex with 5-HT 2A -li showing a widespread distribution. The majority of 5-HT 2A -li cells displayed a pyramidal morphology. While a minority, some cortical neurons with a bipolar morphology displayed 5-HT 2A -li as well. Dual-label fluorescence confocal microscopic studies with a 5-HT 2A antibody and a mouse monoclonal antibody to parvalbumin, a marker of a subset of gamma aminobutyric acid (GABA)ergic interneurons in the cortex, demonstrated that although some cells expressing 5-HT 2A -li were interneurons, most were not. Synapse 27:79-82, 1997.