Serotonergic modulation of the P300 event related brain potential
✍ Scribed by Michel Hansenne; William Pitchot; Patrick Papart; Marc Ansseau
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 92 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0885-6222
No coin nor oath required. For personal study only.
✦ Synopsis
While dopaminergic, noradrenergic, cholinergic and gabaergic eects on the P300 component of the human eventrelated brain potential have been largely described, little is known about serotonergic in¯uence. Therefore, we investigated the relationship between P300 and serotonergic activity as re¯ected by prolactin (PRL) response to ¯esinoxan, a 5-HT1A full agonist, among 28 normal subjects. Results showed a signi®cant negative correlation between P300 amplitude and PRL response to ¯esinoxan (r À0 . 47, p 0 . 01 at Cz; r À0 . 45, p 0 . 01 at Pz). In contrast, both P300 latency and reaction time were not related to endocrine response. This study supports a role for serotonin in the neurobiological modulation of P300 amplitude. Clinical implications of these results are considered.