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Serotonergic effects of clozapine and its metabolites in hippocampal HT22 cells

✍ Scribed by Philip Heiser; Christiane Hausmann; Joachim Frey; Frank Geller; Ralf Becker; Wolfgang Wesemann; Jürgen-Christian Krieg; Helmut Remschmidt; Helmut Vedder


Book ID
117985901
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
130 KB
Volume
112
Category
Article
ISSN
0165-1781

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Pooled plasma from healthy volunteers was spiked with pure, synthetic clozapine or clozapine N-oxide and then made alkaline with either sodium hydroxide or sodium carbonate. The alkalized samples were allowed to stand at room temperature for various time intervals before extraction with organic solv