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Seroprevalence of neutralizing antibodies to human adenovirus type 5 in healthy adults in China

✍ Scribed by Bin Yu; Yan Zhou; Hao Wu; Zhen Wang; Yang Zhan; Xiao Feng; Ranshen Geng; Yongge Wu; Wei Kong; Xianghui Yu

Book ID: 112133284
Publisher: John Wiley and Sons
Year: 2012
Tongue: English
Weight: 168 KB
Volume: 84
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.23325

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## Abstract In vivo gene delivery using human adenovirus serotype 5 (AdV5) vectors is being explored for vaccination purposes. The presence of anti‐AdV5 antibodies in human serum arising from natural exposure to AdV5 can interfere potentially with and compromise the efficacy of rAdV5‐based vaccine