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Serologie HLA typing in cryptogenic Lennox-Gastaut syndrome

✍ Scribed by Baziel G.M. van Engelen; Leo P. de Waal; Corry M.R. Weemaes; Willy O. Renier

Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
422 KB
Volume
17
Category
Article
ISSN
0920-1211

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✦ Synopsis

Serologic HLA typing was performed on 12 patients with cryptogenic Lennox-Gastaut syndrome and compared to a normal control group of 1661 Caucasians. In the Lennox-Gastaut group we found a significant increase in the frequency of DR5 antigen (55%, x2 = 5.6), and an indication of a decrease in the frequency of DR4 antigen (O%, x2 = 3.0) as compared with controls (20% and 28%, respectively). No significant differences existed in the frequencies of HLA-A, B, and C antigens between the Lennox-Gastaut group and the controls.

These findings contribute to the hypothesis that immunogenetic mechanisms may play a role in triggering or maintaining cryptogenic Lennox-Gastaut syndrome.

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