Serological response of multiple sclerosis patients and controls to 6/94-parainfluenza virus

✍ Scribed by J. Wikström; D. W. Meyer; K. Eickhoff; G. Ritter; S. Poser; H. J. Bauer; V. Kratzsch; W. R. Kiessling

• Publisher: Springer
• Year: 1977
• Tongue: English
• Weight: 194 KB
• Volume: 216
• Category: Article
• ISSN: 0340-5354
• DOI: 10.1007/bf00312815

✦ Synopsis

The serological responses of 195 multiple sclerosis (MS) patients and 251 controls were tested against 6/94-parainfluenza virus, which was previously isolated from brain tissue of two patients with MS. The hemagglutination-inhibition titers of greater than or equal to 1: 128 were found more frequently in MS patients (21.5%) than in controls (14.0%). However, the geometric mean titers did not differ between these two groups. The present study concludes that a causal relationship of 6/94-virus to MS, based on a specific immune response, is improbable, although it does not exclude the possibility of a pathogenetic significance of the agent in the cases from which the autopsy material was derived.