Serological markers of hepatitis B, C, and E viruses and human immunodeficiency virus type-1 infections in pregnant women in Bali, Indonesia

✍ Scribed by I Gede Putu Surya; Karkata Kornia; Tjok Gde Agung Suwardewa; Mulyanto; Fumio Tsuda; Shunji Mishiro

• Publisher: John Wiley and Sons
• Year: 2005
• Tongue: English
• Weight: 103 KB
• Volume: 75
• Category: Article
• ISSN: 0146-6615
• DOI: 10.1002/jmv.20314

✦ Synopsis

Abstract

Except for hepatitis B virus (HBV), there have been few data on serological markers of hepatitis viruses such as hepatitis C virus (HCV) and E virus (HEV), and human immunodeficiency virus type‐1 (HIV) in Bali, Indonesia. During 5 months from April to August 2003, sera were collected from 2,450 pregnant women at eight jurisdictions in Bali, and they were tested for markers of these viruses. Only one (0.04%) was positive for antibody to HCV, but none for antibody to HIV. Hepatitis B surface antigen (HBsAg) was detected in 46 (1.9%) at a prevalence significantly lower than that in 271 of the 10,526 (2.6%) pregnant women in Bali surveyed 10 years previously (P < 0.045). The prevalence of hepatitis B e antigen in pregnant women with HBsAg decreased, also, from 50% to 28% during the 10 years (P < 0.011). Antibody to HEV (anti‐HEV) was examined in 819 pregnant women who had been randomly selected from the 2,450. The overall prevalence of anti‐HEV was 18%, and there were substantial regional differences spanning from 5% at Tabanan district to 32% at Gianyar district. Furthermore, the prevalence of anti‐HEV differed substantially by their religions. In the Sanglah area of Denpasar City, for instance, anti‐HEV was detected in 20 of the 102 (20%) Hindus, significantly more frequently than in only 2 of the 101 (2.0%) Muslims (P < 0.001). Swine that are prohibited to Muslims, therefore, is likely to serve as a reservoir of HEV in Bali. In conclusion, HBV is decreasing, HCV and HIV have not prevailed, as yet, while HEV is endemic probably through zoonotic infection in Bali. J. Med. Virol. 75:499–503, 2005. © 2005 Wiley‐Liss, Inc.