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Serological analysis of B6.C-H-2bm12 (I-A mutant)

✍ Scribed by Mauro S. Sandrin; Ian F. C. McKenzie; Roger W. Melvold; Günter J. Hämmerling

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
473 KB
Volume
12
Category
Article
ISSN
0014-2980

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✦ Synopsis

Abstract

The B6.C‐H‐2^bm12^ has been examined serologically with a new set of reagents and several complementation studies were performed to determine the extent of the mutation. The results show that: (a) the mutation has also affected the site(s) bound by xenogeneic anti‐Ia antibodies; (b) the IJ^b^ region was not affected; (c) complementation studies with stains bearing a, b, d, k and s haplotypes did not complement bm12 for the expression of the lost I‐A^b^ specificities, suggesting a structural (rather than regulatory) gene alteration in bm12; (d) H‐2 haplotypes b and bm12 could complement d to establish the Ia.22 specificity, indicating that Ia‐1 and A~c~ are separate genes in the I‐A subregion In addition, an antibody to the gained specificity on bm12 is described.

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