𝔖 Bobbio Scriptorium
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Seroepidemiological study of respiratory syncytial virus in São Paulo State, Brazil

✍ Scribed by Cox, M. J.; Azevedo, R. S.; Cane, P. A.; Massad, E.; Medley, G. F.

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
124 KB
Volume
55
Category
Article
ISSN
0146-6615

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✦ Synopsis

Transmission of respiratory syncytial virus is thought to be highly seasonal based on reported clinical cases, although transmission resulting in mild disease in all age groups has been little studied. This has been investigated in a seroepidemiological survey using sera from Sa ˜o Paulo, Brazil. Seroprevalence was found to increase rapidly with age, reaching over 90% by three years of age. This is typical of viral infections, which produce life-long immunity following primary infection. One-hundred percent seropositivity was attained by five years of age and maintained throughout adulthood, whereas mean antibody titers continued to increase with age. The mean duration of maternal antibodies was estimated to be 3.3 months with antibody decay demonstrated in paired samples from infants. The results are discussed in relation to possible mechanisms generating such a profile.

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