Seroepidemiological studies of human papilloma virus (HPV-1) infections

✍ Scribed by Herbert Pfister; Harald Zur Hausen

• Publisher: John Wiley and Sons
• Year: 1978
• Tongue: French
• Weight: 439 KB
• Volume: 21
• Category: Article
• ISSN: 0020-7136
• DOI: 10.1002/ijc.2910210206

✦ Synopsis

Abstract

At least two groups of human papilloma viruses can be distinguished serologically: on the one hand HPV 1‐3, which are closely related but differ in the restriction enzyme pattern of their DNA, and on the other hand HPV‐4. The age distributions of patients with warts induced by HPV 1‐3 or by HPV‐4, respectively, differ markedly. HPV 1‐3 predominates between 5 and 15 years of age, whereas HPV‐4 could be isolated more often between the ages of 20‐25 years. The large number of HPV‐1‐3‐induced warts in children is paralleled by a high percentage of HPV‐1 antibody‐positive sera in the same age group (about 50%). With increasing age the percentage of HPV‐1 antibody‐positive sera declines gradually. This pattern of seroreactivity was compared to that of patients with various papillomas and with several malignant tumors. There is no evidence to suggest a link between HPV 1‐3 and condylomata acuminata, laryngeal papillomas or any of the malignant tumors tested.