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Serial P-31 MR spectroscopy after fructose infusion in patients with chronic hepatitis

✍ Scribed by Hajime Sakuma; Kenji Itabashi; Kan Takeda; Tadanori Hirano; Yasutomi Kinosada; Tsuyoshi Nakagawa; Masao Yamada; Takeshi Nakano

Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
372 KB
Volume
1
Category
Article
ISSN
1053-1807

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✦ Synopsis

Abstract

Serial changes in phosphorus metabolites after intravenous administration of fructose were compared between five healthy volunteers and five patients with chronic hepatitis by means of phosphorus‐31 magnetic resonance (MR) spectroscopy. P‐31 spectra were obtained every 5 minutes after intravenous drip infusion of 20% fructose at a dose of 0.5 g/kg of body weight. In the healthy volunteers, phosphomonoesters (PME) increased to 338% ± 76% of the preadministration value at 15‐20 minutes. Inorganic phosphate (Pi) was depleted in the first 15 minutes, then rebounded to 260% ± 67% of the initial value. β‐adenosine triphosphate decreased to less than 50% of its initial value and then gradually recovered. In patients with chronic hopatitis, the increase of PME at 15‐20 minutes (151% ± 49% of the preadministration value) was significantly less than that in healthy volunteers (p <.05). In addition, the rebound of pi at 35‐40 minutes (126% ± 42%) was significantly less than that in healthy volunteers (P <.05). IN conclusion, P‐31 MR Spectroscopy with fructose administration is valuable in the fuctional evaluation of diffuse liver diseases.

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