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Serial double nucleophilic addition of amines to the imidazole nucleus

✍ Scribed by Shunsaku Ohta; Tomohisa Osaki; Satoko Nishio; Akemi Furusawa; Masayuki Yamashita; Ikuo Kawasaki

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
590 KB
Volume
41
Category
Article
ISSN
0040-4039

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✦ Synopsis

2-(1-Chloro-2,2-dimethylpropyl)-1-methyl-1H-imidazole hydrochloride (2aβ€’HCl) was treated with an excess of N,N-dimethylamine at room temperature to give an abnormal addition product, 4,5-bis

The former might be evolved from a serial double nucleophilic addition of the secondary amine molecules to the imidazole nucleus, which has been generally considered as an electron-excessive and stable aromatic ring.

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