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SERCA2a in Heart Failure: Role and Therapeutic Prospects

✍ Scribed by Davide Gianni; Joachim Chan; Judith K. Gwathmey; Federica del Monte; Roger J. Hajjar


Publisher
Springer US
Year
2005
Tongue
English
Weight
79 KB
Volume
37
Category
Article
ISSN
0145-479X

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In end-stage heart failure the expression of different myocardial regulatory proteins involved in the beta-adrenergic cAMP signalling pathway is altered. The downregulation of beta 1-adrenoceptors and their uncoupling from the effector as well as an increased expression of the inhibitory GTP-binding