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Sequential Unfolding of Ankyrin Repeats in Tumor Suppressor p16

โœ Scribed by Kit S Tang; Alan R Fersht; Laura S Itzhaki

Book ID
114329204
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
150 KB
Volume
11
Category
Article
ISSN
0969-2126

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To identify whether alterations of the p16 tumor suppressor gene are a common event in localized prostate cancer, we examined the frequency of p16 gene mutations in 30 primary tumors. Only two tumors demonstrated altered single-strand conformation polymorphism patterns for exon 2 of p16. In both cas