BACKGROUND.
The optimal management of inoperable desmoid tumors is still unclear. We report a 26 year-old female patient with familial adenomatous polyposis suffering from a recurrent inoperable intraabdominal desmoid tumor and its sequential treatment. METHODS. Treatment strategies included low-dose tamoxifen (30 mg orally per day), high-dose tamoxifen (90 mg orally per day), and a subsequent combination of goserelin acetate (3.6 mg subcutaneously once every four weeks) plus low-dose tamoxifen, medroxyprogesterone acetate (1000 mg orally per day) and interferon gamma (3 Mio IU subcutaneously 3 times a week). RESULTS. The combination of goserelin acetate and low-dose tamoxifen resulted in a decrease in tumor size and a complete relief of symptoms for 17 months. Thereafter the tumor progressed and again growth was stopped with interferon gamma therapy for another 6 months. All other treatment modalities had no effect. CONCUISIONS. This study demonstrates long-term regression of a desmoid tumor with combined endocrine therapy using goserelin acetate plus tarnoxifen. Tumor progression after 17 months was again stopped by a combination of interferongamma and goserelin acetate. Cancer 199s; 721061-5.
6 1996 American Cancer Sociery.