Sequential Reactions of Trimethylsilyldiazomethane with 4-Alkenyl Ketones and Aldehydes Catalyzed by Lewis Bases
✍ Scribed by Liu, Huaqing; O’Connor, Matthew J.; Sun, Chunrui; Wink, Donald J.; Lee, Daesung
- Book ID
- 120371248
- Publisher
- American Chemical Society
- Year
- 2013
- Tongue
- English
- Weight
- 608 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1523-7060
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In the Baylis-Hillman reaction of arylaldehydes with methyl vinyl ketone, we found that, in the presence of a catalytic amount of L-proline, weak Lewis bases such as imidazole and triethylamine as well as the stronger Lewis base DABCO, can promote the Baylis-Hillman reaction to give the normal Bayli