Sequential One-Pot Reactions Using the Concept of “Site Isolation”
✍ Scribed by Brigitte Voit
- Publisher
- John Wiley and Sons
- Year
- 2006
- Weight
- 8 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0931-7597
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## Abstract The first and second generation Grubbs’ catalysts are shown to convert cyclohexane and cyclohexene bis‐allyl and allyl propargyl ethers into 6,8‐fused bicyclic derivatives by alkene and enyne metathesis reactions, respectively. The corresponding cyclohexane and cyclohexene bis‐propargyl
1,4-Disubstituted 1,3-dialkynes were obtained from the one-pot palladium/copper-catalyzed coupling reactions of aryl iodide and propiolic acid. The optimized catalytic system consisted of 5.0 mol % Pd(PPh 3 ) 2 Cl 2 , 10 mol % dppb, 10 mol % CuI, 2.4 equiv of DBU, and 1.2 equiv of K 2 CO 3 . The cou