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Sequential methotrexate–5-fluorouracil treatment of squamous cell carcinoma of the head and neck

✍ Scribed by Ulrik Ringborg; GÖSta Ewert; Jan Kinnman; Per-Gotthard Lundqvist; Hans Strander

Publisher
John Wiley and Sons
Year
1983
Tongue
English
Weight
271 KB
Volume
52
Category
Article
ISSN
0008-543X

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✦ Synopsis

Thirty-six patients with squamous cell carcinoma of the head and neck were treated with sequential methotrexate-5-fluorouracil followed by leucovorin rescue. The frequency of objective tumor regression obtained was 64% (complete response + partial response) with 19% complete regression. In 20 not previously treated patients, the objective response rate was 70%. Approximately the same result was obtained for tumors of different anatomical sites of the head and neck. The degree of differentiation of the squamous cell carcinoma did not seem to be of prognostic importance for the initial tumor response. Toxicity was very mild and usually disappeared when the interval between the chemotherapy courses was prolonged from 1 to 2 weeks. Radiotherapy could be added sequentially to the treatment without measurable escalated toxicity.

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