Mitoxantrone (M) is a synthetic aminoanthraquinone with anti-leukemic activity in patients with daunorubicin (D) resistant acute leukemia. The Cancer and Leukemia Group B (CALGB) has undertaken a limited access pilot study in which M, 12 mg/m2, over 30 min, daily for 3 days, and cytosine arabinoside
Sequential intermediate-dose cytosine arabinoside and mitoxantrone for patients with relapsed and refractory acute myelocytic leukemia
β Scribed by Paolo Alberto Paciucci; Janet Cuttner; James F. Holland
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 389 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0361-8609
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Twenty-five adult patients with refractory acute lymphocytic leukemia received salvage therapy with mitoxantrone 5 mg/m2 intravenously over 1 hour daily for 5 days and cytosine arabinoside 3 g/m2 intravenously over 2 hours every 12 hours for six doses. Overall, nine patients (36%) achieved complete
Department of Heremission whereas 5 patients (23%) succumbed to early death and 3 patients (14%) matology and Oncology, Go Β¨ttingen, Germany. did not respond. Blood counts recovered at a median of 33.5 days after the start 2 Westfa Β¨lische Wilhelms University, Department of treatment and complete r