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Sequential elaboration of lymphocyte-enhancing and -suppressing factors in the sera of tumor-bearing animals

โœ Scribed by Alan G. Wile; Robert A. Cohen; Theresa M. Terem; Michael F. Contino; Rita Kar

Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
491 KB
Volume
35
Category
Article
ISSN
0022-4790

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โœฆ Synopsis

Serum-mediated impairment of lymphocyte function was studied in an animal model. Sprague-Dawley rats inoculated intraperitoneally or subcutaneously with the Walker 256 carcinoma underwent sequential sampling of blood. The effect of these serum samples upon phytohemagglutinin-induced blastogenesis of normal rat splenocytes was monitored in an assay utilizing incorporation of (3H)-thymidine. The effect of serum samples from both the subcutaneously and the intraperitoneally inoculated tumor-bearing animals was biphasic. Early on, serum enhanced blastogenesis and later suppressed blastogenesis. Separation of sera into high and low molecular weight components by ultrafiltration demonstrated the enhancing activity to reside in the high molecular weight fraction. The enhancing activity of sera decreased over time from tumor inoculation. Conversely, suppressor activity increased over time from tumor inoculation. This study demonstrated that suppressor activity of sera obtained from animals with advanced tumors is the result of the lack of enhancing activity coupled with the elaboration of suppressor activity.

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## Abstract Culture supernatants of spleen cells from tumorโ€bearing mice (TBM) have been found to enhance tumor growth, when injected together with tumor cells, and to augment the generation of antibodyโ€producing cells (APC), when injected into mice together with sheep erythrocytes (SRBC). In an at