Sequential design with boundaries approach in pediatric intervention research reduces sample size

Reducing sample sizes in genome scans: G

Reducing sample sizes in genome scans: Group sequential study designs with futility stops

✍ Inke R. König; Helmut Schäfer; Andreas Ziegler; Hans-Helge Müller 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 148 KB

## Abstract Group sequential study designs can greatly facilitate analyses of genetic linkage in complex traits. We recently proposed designs allowing stopping investigations early if the result is significant (König et al. [2001] Am. J. Hum. Genet. 69:590–600), thereby decreasing average sample si