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Sequential design of phase II–III cancer trials

✍ Scribed by Tze Leung Lai; Philip W. Lavori; Mei-Chiung Shih


Book ID
112207070
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
231 KB
Volume
31
Category
Article
ISSN
0277-6715

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The objective of a phase II cancer clinical trial is to screen a treatment that can produce a similar or better response rate compared to the current treatment results. This screening is usually carried out in two stages as proposed by Simon. For ineffective treatment, the trial should terminate at