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Sequential coagulation factor VIIa domain binding to tissue factor

✍ Scribed by Maria Österlund; Egon Persson; Uno Carlsson; Per-Ola Freskgård; Magdalena Svensson

Book ID
116291586
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
355 KB
Volume
337
Category
Article
ISSN
0006-291X

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✍ Daniel Kirchhofer; Yale Nemerson 📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 637 KB

Tissue factor (TF), a transmembrane glycoprotein, functions as an essential activator of the serine protease factor Vlla. This enzymatic complex is considered to be the principal initiator of in vivo coagulation. Recent studies emphasize the role of the TF/Vlla complex in a number of pathophysiologi