✦ LIBER ✦

Sequential changes of programmed cell death in developing fetal mouse limbs and its possible roles in limb morphogenesis

✍ Scribed by Sumiko Kimura; Kohei Shiota

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 935 KB
Volume: 229
Category: Article
ISSN: 0362-2525
DOI: 10.1002/(sici)1097-4687(199609)229:3<337::aid-jmor8>3.0.co;2-v

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✦ Synopsis

Apoptotic cell death in the developing limb of mouse fetuses was examined sequentially on days 11-15 of gestation by means of Nile blue (NB) sulfate staining with special reference to its relation to limb morphogenesis. With some exceptions, programmed cell death (PCD) in the hand and foot was observed in the mesenchyme but not in the surface ectoderm. We found that during digital formation PCD begins at the proximal portion of the interdigital

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