✦ LIBER ✦
Sequential appearance of intestinal mucosal cell types in the right and caudate liver lobes of furan-treated rats
✍ Scribed by Lynne W. Elmore; Dr. Alphonse E. Sirica
- Publisher
- John Wiley and Sons
- Year
- 1992
- Tongue
- English
- Weight
- 858 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0270-9139
No coin nor oath required. For personal study only.
✦ Synopsis
Furan rapidly induces in rat liver a unique, lobespecific pattern of development of intestinal metaplasia and associated cholangiofibrosis. To establish early cell-precursor relationships in the genesis of this cholangiofibrosis, a time-course study was conducted in which young adult male Fisher 344 rats received furan by gavage at a daily dose of 45 mg/kg body wt over a 32-day treatment period. An analysis of individual