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Sequential administration of methotrexate and asparaginase in relapsed or refractory pediatric acute myeloid leukemia

✍ Scribed by Buaboonnam, Jassada; Cao, Xueyuan; Pauley, Jennifer L.; Pui, Ching-Hon; Ribeiro, Raul C.; Rubnitz, Jeffrey E.; Inaba, Hiroto


Book ID
120233021
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
79 KB
Volume
60
Category
Article
ISSN
1545-5009

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Methotrexate and asparaginase combinatio
✍ Jeffrey S. Lobel; Richard T. O'Brien; Sue McIntosh; Gregg T. Aspnes; Robert L. C πŸ“‚ Article πŸ“… 1979 πŸ› John Wiley and Sons 🌐 English βš– 526 KB

Two groups of children with refractory acute lymphoblastic leukemia were treated with a regimen of methotrexate (MTX) and asparaginase (Asn'ase) based on studies of the effect of MTX in vitro on human lymphoblasts exposed to Asn'ase. Induction therapy in 12 children produced 4 complete remissions, 3