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Sequential activation of individual caspases, and of alterations in Bcl-2 proapoptotic signals in a mouse model of Huntington's disease

✍ Scribed by Yu Zhang; Victor O. Ona; Mingwei Li; Martin Drozda; Michel Dubois-Dauphin; Serge Przedborski; Robert J. Ferrante; Robert M. Friedlander


Book ID
111178139
Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
32 KB
Volume
87
Category
Article
ISSN
0022-3042

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Riluzole prolongs survival time and alte
✍ Johannes Schiefer; G. Bernhard Landwehrmeyer; Hans-Gerd LΓΌesse; Arne SprΓΌnken; C πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 375 KB

Glutamate excitotoxicity has been suggested to contribute to the pathogenesis of Huntington's disease (HD). Riluzole is a substance with glutamate antagonistic properties that is used for neuroprotective treatment in amyotrophic lateral sclerosis and which is currently tested in clinical trials for